Applications
| Reactive Species | Human, Mouse, Rat |
| Specificity | Mono-Methylated-NFκB-p65 (K314/K315) Polyclonal Antibody detects endogenous levels of p65 protein only when mono-Methylatedated at K314/K315. |
| Applications | WB, ELISA |
| Recommended Dilution | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
Product Information
| Product Name | NFκB-p65 (Mono Methylated Lys314/Lys315) pAb |
| Antibody Type | Rabbit pAb |
| Immunogen | Synthesized peptide derived from human p65 around the mono-Methylatedation site of K314/K315. |
| Modification | Mono Methylated |
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Conditions | -15°C to -25°C/1 year (Do not lower than -25°C). |
Background Information
| Function | NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011], |
| UniProt ID | Q04206 |
| Organism | Human |
| Recommended Name | Transcription factor p65 |
| Short Name | NFkB p65 |
| Alternative Names | RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3. |
| Gene ID | 5970 |
| Gene Name | RELA |
| Calculated MW | N/A |
| Observed MW | 60 kDa |
| Subcellular Location | Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622). |
| Summary | N/A |
| Pathways | N/A |
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NFκB-p65 (Mono Methylated Lys314/Lys315) pAb
1,380.00
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