Applications
| Reactive Species | Human, Mouse, Rat |
| Specificity | The antibody detects endogenous Histone H4 (Mono Methylatedl Lys79) protein. |
| Validated Applications | WB |
| Recommended Dilution | WB 1:500-1000 |
Product Information
| Product Name | Histone H4 (Mono Methylatedl Lys79) Mouse pAb |
| Antibody Type | Mouse pAb |
| Immunogen | Synthetic Peptide of Histone H4 (Mono Methylatedl Lys79) |
| Modification | Methylated |
| Host | Mouse |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | N/A |
| Conjugation | Unconjugated |
| Form | Liquid |
| Concentration | N/A |
| Purification Method | Immunogen affinity purification |
| Storage Buffer | PBS (pH 7.4) containing 0.5% BSA, 0.02% New type preservative N as Preservative and 50% Glycerol. |
| Storage Conditions | Store at 2-8°C for up to 2 weeks. Store at -15°C to -25°C for 1 year. Aliquot to avoid freeze / thaw cycle. |
Background Information
| Function | function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Acetylatedation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.,PTM:Citrullination at Arg-4 by PADI4 impairs Methylatedlation.,PTM:MonoMethylatedlated, diMethylatedlated or triMethylatedlated at Lys-21. MonoMethylatedlation is performed by SET8. TriMethylatedlation is performed by SUV420H1 and SUV420H2 and induces gene silencing.,PTM:MonoMethylatedlation at Arg-4 by PRMT1 favors Acetylatedation at Lys-9 and Lys-13. DeMethylatedlation is performed by JMJD6.,PTM:Sumoylated, which is associated with transcriptional repression.,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.,similarity:Belongs to the histone H4 family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA., |
| UniProt ID | P62805 |
| Organism | Human |
| Recommended Name | Histone H4 |
| Short Name | N/A |
| Alternative Names | H4K79ME1, HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4, Histone H4. |
| Gene ID | 121504 |
| Gene Name | HIST1H4A, H4/A, H4FA;, HIST1H4B, H4/I, H4FI;, HIST1H4C, H4/G, H4FG;, HIST1H4D, H4/B, H4FB;, HIST1H4E, H4/J, H4FJ;, HIST1H4F, H4/C, H4FC;, HIST1H4H, H4/H, H4FH;, HIST1H4I, H4/M, H4FM;, HIST1H4J, H4/E, H4FE;, HIST1H4K, H4/D, H4FD;, HIST1H4L, H4/K, H4FK;, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4;, HIST2H4B, H4/O, H4FO;, HIST4H4 |
| Calculated MW | 14 kDa |
| Observed MW | N/A |
| Subcellular Location | Nucleus. Chromosome. |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015], |
| Pathways | Systemic lupus erythematosus; |
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Histone H4 (Mono Methylatedl Lys79) Mouse pAb
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